The Ocean Biomolecular Observing Network (OBON), an endorsed global programme of the UN Decade of Ocean Science for Sustainable Development, aims to transform how we sense, harvest, protect, and manage ocean life, which is threatened by anthropogenic stressors and climate change. OBON aims to help communities detect biological hazards like harmful algal blooms, pathogens and be a key component of next-generation ocean observing systems. To achieve this vision, with our endorsed Projects, we ensure biomolecular ocean observations are globally coordinated, harmonized, FAIR, and reliably flow into the global ocean observing system as standard practice integral to sustainable ocean management. OBON acts as a strategic hub bringing biomolecular knowledge and capacity to diverse ocean users. OBON’s core pillars are: (1) Innovate technology, methodologies and frameworks advancing biomolecular observations from coasts to oceans, enabling broad-scale interpretations and scientific discovery; (2) Develop resources, networks and capacity to advance observations while ensuring equitable access to knowledge and resources; and (3) Enhance use and interpretation of data through FAIR data practices and model integration. Together, this (4) Informs users and managers, ensuring sustainable interactions in support of healthy oceans. We provide an overview of OBON, recent developments, and ways for the global community to engage.